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Intracardial injections with 1 ml of 1% sodium nitrite and 1000 units of sodium heparin were made to reduce coagulation and increase vasodilation.
Management of this condition is difficult and various vasodilators have been unsuccessful in providing preferential pulmonary vasodilation.
In the acute early phase there is vasodilation with the classical, full, bounding pulsation and arterial bruit.
Our study has shown that it is combined administration of nitric oxide and beraprost which 30 produces maximal pulmonary vasodilation.
The management of this condition is difficult and different types of vasodilators have not succeeded in producing preferential pulmonary vasodilation.
Accordingly, the selectivity of pulmonary vasodilation may be overestimated in the setting of loading with nitric oxide.
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Beraprost, therefore, is a safe and effective vasodilator which provides preferential pulmonary vasodilation in infants and children with pulmonary hypertension secondary to congenital heart disease.
Acetylcholine increases pulmonary blood flow in intact fetuses via endothelium-dependent vasodilation.
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