Is it the geometry, the charged heads, the hydrophilic nature of the heads, or maybe something else?

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Since these proteins are hydrophilic, they were speculated to protect the embryo during desiccation.
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The option of facilitated transport of hydrophilic ligands to engage intracellular receptors is little used for signaling, however, suggesting that transmembrane receptors are more effective.
In contrast, the more hydrophilic surface of the coated slides resulted in complete wetting of the surface by the medium.
In this arrangement, outwardly facing hydrophobic residues interact with the lipid membrane, while the inwardly facing hydrophilic surfaces form the central lumen of the pore.
These results showed how the overall force curve changes continuously as an initially hydrophilic surface becomes progressively more hydrophobic.
The residues between hydrophobic and hydrophilic trains, denoted by black circles in the figure, are free to wander on the interface.
As another example, the heads in this paper are hydrophilic, and in fact comparable to “attached water beads”.

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The solventmediated hydrophilic interaction plays a key role in determining the structural specificity of globular proteins and contributes to their funneled energy landscape.
Figs 2 and 5) is that polypeptide released in trans is ejected directly into the bulk solution instead of into a sequestered, hydrophilic cis cavity.

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